Test for Fibrinogen/Fibrin Degradation Products (FDPs)
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Hematology

Test for Fibrinogen/Fibrin Degradation Products (FDPs)

Learn about the fibrinogen test procedure to measure fibrin degradation products (FDPs). Discover how increased FDP levels can indicate conditions like DIC, thrombosis, pneumonia, and myocardial infarction.

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Test tube with blood sample for fibrinogen test, coagulation disorder diagnosis.
Test tube with blood sample for fibrinogen test, coagulation disorder diagnosis. Shutterstock / Jarun Ontakrai

Fibrin degradation products (FDPs) are generated through the proteolytic breakdown of fibrinogen or fibrin by plasmin. To measure FDPs, a blood sample is first collected in a tube containing thrombin, which facilitates the conversion of fibrinogen into a clot, thereby removing it from the sample. Additionally, soybean trypsin inhibitor is used to inhibit plasmin activity, preventing the in vitro degradation of fibrin.

The test procedure involves mixing a suspension of latex particles, which are conjugated with antifibrinogen antibodies (or fragments D and E), with serial dilutions of the patient's serum on a glass slide. The presence of FDPs is indicated by agglutination of the latex particles, as shown in Figure 1. The highest serum dilution at which agglutination is observed is used to determine the concentration of FDPs in the sample.

Latex Agglutination Test for Fibrinogen and Fibrin Degradation Products
Figure 1: Principle of latex agglutination test for fibrinogen/fibrin degradation products.

Elevated levels of FDPs are indicative of fibrinogenolysis or fibrinolysis, which can occur in conditions such as disseminated intravascular coagulation, deep venous thrombosis, severe pneumonia, and recent myocardial infarction. This test is critical for diagnosing and monitoring these conditions.

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Dayyal Dg.. “Test for Fibrinogen/Fibrin Degradation Products (FDPs).” BioScience. BioScience ISSN 2521-5760, 03 August 2017. <https://www.bioscience.com.pk/en/topics/hematology/test-for-fibrinogen-fibrin-degradation-products-fdps>. Dayyal Dg.. (2017, August 03). “Test for Fibrinogen/Fibrin Degradation Products (FDPs).” BioScience. ISSN 2521-5760. Retrieved September 17, 2024 from https://www.bioscience.com.pk/en/topics/hematology/test-for-fibrinogen-fibrin-degradation-products-fdps Dayyal Dg.. “Test for Fibrinogen/Fibrin Degradation Products (FDPs).” BioScience. ISSN 2521-5760. https://www.bioscience.com.pk/en/topics/hematology/test-for-fibrinogen-fibrin-degradation-products-fdps (accessed September 17, 2024).
  • Posted by Dayyal Dg.

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