Neutrophil disorders and their management
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Immunology

Neutrophil disorders and their management

Neutrophil disorders are an uncommon yet important cause of morbidity and mortality in infants and children. This article is an overview of these conditions, with emphasis on clinical recognition, rational investigation, and treatment.

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Neutrophil disorders and their management
Neutrophil disorders and their management

Neutrophil disorders are an uncommon yet important cause of morbidity and mortality in infants and children. This article is an overview of these conditions, with emphasis on clinical recognition, rational investigation, and treatment.

Neutrophil disorders

  • Disorders of neutrophil number (neutropenia)
  • Disorders of neutrophil function

Neutrophil disorders are an uncommon, yet important, cause of morbidity and mortality in infants and children and should be considered when investigating children for immunodeficiency. They are especially likely when the clinical presentation includes features such as oral ulcers and gingivitis, delayed separation of the umbilical cord, uncommon infections such as hepatic or brain abscesses, uncommon organisms such as S marcescens or Pseudomonas spp, or when the individual has features of syndromic conditions associated with neutropenia or neutrophil dysfunction. All patients with recurrent oral infections, skin abscesses, perianal and perirectal abscesses, poor wound healing, sinopulmonary infections, or deep visceral abscesses should be evaluated for defects in phagocyte function. Appropriate investigations can lead to specific diagnoses, and general and specific management measures can reduce both mortality and morbidity and permit genetic counselling and antenatal diagnosis in some cases.

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BS Media. “Neutrophil disorders and their management.” BioScience. BioScience ISSN 2521-5760, 27 September 2016. <https://www.bioscience.com.pk/en/topics/immunology/neutrophil-disorders-and-their-management>. BS Media. (2016, September 27). “Neutrophil disorders and their management.” BioScience. ISSN 2521-5760. Retrieved January 06, 2023 from https://www.bioscience.com.pk/en/topics/immunology/neutrophil-disorders-and-their-management BS Media. “Neutrophil disorders and their management.” BioScience. ISSN 2521-5760. https://www.bioscience.com.pk/en/topics/immunology/neutrophil-disorders-and-their-management (accessed January 06, 2023).
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