Estimation of Creatinine Clearance from Serum Creatinine by Prediction Equations

GFR estimation can be derived from the age, sex, body weight, and serum creatinine value of an individual using the formula established by Cockcroft and Gault:

Creatinine clearance in ml/min = [(140 - Age in years) × (Body weight in kg)] ÷ (72 × Serum creatinine in mg/dl)

For females, the outcome derived from the above equation is multiplied by 0.85 to get the result.

It is recommended by National Kidney Foundation (USA) to calculate creatinine clearance by Cockcroft and Gault or other equation from serum creatinine value rather than estimating creatinine clearance from a 24-hour urine sample. This recommendation stems from the inconvenience, time consumption, and potential inaccuracy associated with estimating creatinine clearance through a 24-hour urine sample.