Displaying items by tag: Blood Diseases and Disorders

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Thursday, 03 August 2017 13:15

LABORATORY TESTS IN PORPHYRIAS

Figure 817.1 Figure on left shows steps in the biosynthesis of heme. Some steps (first and last three) occur in mitochondria, while some occur in cytosol. Figure on right shows deficiency state associated with each enzyme. Deficiency of ALA synthase is associated with sideroblastic anemia, and deficiencies of other enzymes cause porphyria
Published in Clinical Pathology
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Thursday, 03 August 2017 11:55

PLATELET GLYCOPROTEIN ANALYSIS

Detection of platelet specific IgG antibodies to platelet glycoproteins (GP) IIb/IIIa, Ia/IIa, Ib/IX, IV or HLA class I (GP IIb/IIIa in this example) by MACE assay. Washed platelets were first incubated with human plasma (containing anti-platelet GP IIb/IIIa in this sample). The antibody-sensitized platelets were then lysed and the supernatant was added to a microplate precoated with murine monoclonal antibodies (MoAb) specific to platelet GP or HLA class I. Any human IgG bound to the GP or HLA class I antigen were detected with a alkaline phosphatase (ALP) conjugated antihuman IgG and substrate solution.
Published in Hemotology
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Thursday, 03 August 2017 11:33

TEST FOR D-DIMER

D-DIMER
Published in Hemotology
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Thursday, 03 August 2017 08:02

TEST FOR FIBRINOGEN/FIBRIN DEGRADATION PRODUCTS (FDPs)

Figure 814.1 Principle of latex agglutination test for fibrinogen/fibrin degradation products
Published in Hemotology
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Friday, 28 July 2017 05:05

PLATELET AGGREGATION STUDIES

Table 804.1 Laboratory features of platelet function disorders
Published in Hemotology
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Wednesday, 26 July 2017 12:45

MORPHOLOGY OF PLATELETS

Figure 802.1 Causes of false thrombocytopenia on automated hematology analyzer: (A) Clumps of platelets; (B) Platelet satellitism
Published in Hemotology
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Wednesday, 26 July 2017 11:28

NUMERICAL ABNORMALITIES OF LEUKOCYTES

Figure 801.1 Numerical abnormalities of white blood cells: (A) Neutrophilia; (B) Eosinophilia; (C) Monocytosis; (D) Lymphocytosis
Published in Hemotology
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Wednesday, 26 July 2017 08:33

WHITE BLOOD CELLS MORPHOLOGY

FORMS OF LEUKOCYTES
Published in Hemotology
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Tuesday, 25 July 2017 13:19

RED CELLS MORPHOLOGY

Figure 799.1: Variations in size and shape of red cells: (A) Microcytic hypochromic red cells in iron deficiency anemia; (B) Oval macrocytes and a hypersegmented neutrophil in megaloblastic anemia; (C) Sickle cells in sickle cell anemia; (D) Spherocytes in hereditary spherocytosis; (E) Fragmented red cells or schistocytes in microangiopathic hemolytic anemia; (F) Target cells in hemoglobinopathy; (G) Burr cells in chronic renal failure; (H) Tear drop red cells in myelofibrosis; (I) Bite cells and (J) Blister cell in glucose-6-phosphate dehydrogenase deficiency
Published in Hemotology
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