Displaying items by tag: Blood Diseases and Disorders

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Figure 817.1 Figure on left shows steps in the biosynthesis of heme. Some steps (first and last three) occur in mitochondria, while some occur in cytosol. Figure on right shows deficiency state associated with each enzyme. Deficiency of ALA synthase is associated with sideroblastic anemia, and deficiencies of other enzymes cause porphyria

LABORATORY TESTS IN PORPHYRIAS

Published in Clinical Pathology
on 03 Aug 2017

Detection of platelet specific IgG antibodies to platelet glycoproteins (GP) IIb/IIIa, Ia/IIa, Ib/IX, IV or HLA class I (GP IIb/IIIa in this example) by MACE assay. Washed platelets were first incubated with human plasma (containing anti-platelet GP IIb/IIIa in this sample). The antibody-sensitized platelets were then lysed and the supernatant was added to a microplate precoated with murine monoclonal antibodies (MoAb) specific to platelet GP or HLA class I. Any human IgG bound to the GP or HLA class I antigen were detected with a alkaline phosphatase (ALP) conjugated antihuman IgG and substrate solution.

PLATELET GLYCOPROTEIN ANALYSIS

Published in Hemotology
on 03 Aug 2017

D-DIMER

TEST FOR D-DIMER

Published in Hemotology
on 03 Aug 2017

Figure 814.1 Principle of latex agglutination test for fibrinogen/fibrin degradation products

TEST FOR FIBRINOGEN/FIBRIN DEGRADATION PRODUCTS (FDPs)

Published in Hemotology
on 03 Aug 2017

Table 804.1 Laboratory features of platelet function disorders

PLATELET AGGREGATION STUDIES

Published in Hemotology
on 28 Jul 2017

Figure 802.1 Causes of false thrombocytopenia on automated hematology analyzer: (A) Clumps of platelets; (B) Platelet satellitism

MORPHOLOGY OF PLATELETS

Published in Hemotology
on 26 Jul 2017

Figure 801.1 Numerical abnormalities of white blood cells: (A) Neutrophilia; (B) Eosinophilia; (C) Monocytosis; (D) Lymphocytosis

NUMERICAL ABNORMALITIES OF LEUKOCYTES

Published in Hemotology
on 26 Jul 2017

FORMS OF LEUKOCYTES

WHITE BLOOD CELLS MORPHOLOGY

Published in Hemotology
on 26 Jul 2017

Figure 799.1: Variations in size and shape of red cells: (A) Microcytic hypochromic red cells in iron deficiency anemia; (B) Oval macrocytes and a hypersegmented neutrophil in megaloblastic anemia; (C) Sickle cells in sickle cell anemia; (D) Spherocytes in hereditary spherocytosis; (E) Fragmented red cells or schistocytes in microangiopathic hemolytic anemia; (F) Target cells in hemoglobinopathy; (G) Burr cells in chronic renal failure; (H) Tear drop red cells in myelofibrosis; (I) Bite cells and (J) Blister cell in glucose-6-phosphate dehydrogenase deficiency

RED CELLS MORPHOLOGY

Published in Hemotology
on 25 Jul 2017