Hemotology

Blood Group Systems

Blood Group Systems

  • Dayyal Dg.
  • | 21 Mar 2019
International Society of Blood Transfusion (ISBT) Working Party has organized red cell antigens into 25…
Thursday, 31 January 2019 14:35

Preparation of Blood Components From Whole Blood for Transfusion

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Preparation of Blood Components From Whole Blood for Transfusion
A single whole blood donation can be separated into different components to provide treatment to…
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Tuesday, 29 January 2019 08:42

Screening Tests for Infections Transmissible by Transfusion

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Screening Tests for Infections Transmissible by Transfusion
The organisms likely to be transmitted by transfusion are usually those, which are prevalent in…
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Tuesday, 29 January 2019 06:23

Adverse Effects of Transfusion

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Adverse Effects of Transfusion
Blood transfusion is a life-saving procedure in an appropriate setting and there are no side-effects…
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Thursday, 03 August 2017 11:55

PLATELET GLYCOPROTEIN ANALYSIS

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Detection of platelet specific IgG antibodies to platelet glycoproteins (GP) IIb/IIIa, Ia/IIa, Ib/IX, IV or HLA class I (GP IIb/IIIa in this example) by MACE assay. Washed platelets were first incubated with human plasma (containing anti-platelet GP IIb/IIIa in this sample). The antibody-sensitized platelets were then lysed and the supernatant was added to a microplate precoated with murine monoclonal antibodies (MoAb) specific to platelet GP or HLA class I. Any human IgG bound to the GP or HLA class I antigen were detected with a alkaline phosphatase (ALP) conjugated antihuman IgG and substrate solution.
This is done by flow cytometric analysis for detection of lack of GpIb/IX in Bernanrd…
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Thursday, 03 August 2017 11:33

TEST FOR D-DIMER

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D-DIMER
D-dimer is derived from the breakdown of fibrin by plasmin and D-dimer test is used…
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Thursday, 03 August 2017 08:02

TEST FOR FIBRINOGEN/FIBRIN DEGRADATION PRODUCTS (FDPs)

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Figure 814.1 Principle of latex agglutination test for fibrinogen/fibrin degradation products
FDPs are fragments produced by proteolytic digestion of fibrinogen or fibrin by plasmin. For determination…
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Monday, 31 July 2017 12:06

PRINCIPLES OF WORKING OF AUTOMATED HEMOTOLOGY ANALYZER

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AUTOMATED HEMOTOLOGY ANALYZER
Automated hematology analyzers work on different principles:   Electrical impedance Light scatter Fluorescence Light absorption…
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Sunday, 30 July 2017 13:20

ADVANTAGES AND DISADVANTAGES OF AUTOMATED HEMOTOLOGY ANALYZER

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AUTOMATED HEMOTOLOGY ANALYZER
AUTOMATED HEMOTOLOGY ANALYZER Automation is a process of replacement of tasks hitherto performed by humans…
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Saturday, 29 July 2017 14:18

CAUSES OF ERRONEOUS RESULTS (INTERFERENCES CAUSING ABNORMAL RESULT) WITH HEMOTOLOGY ANALYZER

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Table 809.1 Causes of erroneous results with hematology analyzer
CAUSES OF ERRONEOUS RESULTS (INTERFERENCES CAUSING ABNORMAL RESULT)   These are listed in Table 809.1…
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Saturday, 29 July 2017 12:54

PARAMETERS MEASURED BY HEMATOLOGY ANALYZERS

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ADVIA 360 System, ADVIA 560 System, and ADVIA 560 AL System offering state-of-the-art hematology testing. High quality complete blood count testing, running up to 60 samples per hour. Designed for small to mid-sized laboratories and hospitals. The ADVIA 360 System measures 22 parameters, including a 3-part white cell differential and storage capacity of 10,000 results. The ADVIA 560 System and ADVIA 560 AL System measure 26 parameters, including a 5-part white blood cell differential and storage capacity of 100,000 results.
Parameters measured by hematology analyzers and their derivation are shown in Tables 808.1 and 808.2.…
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Saturday, 29 July 2017 10:37

FLOW CYTOMETRY

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Principle of working of a flow cytometer
FLOW CYTOMETRY   Flow cytometry is a procedure used for measuring multiple cellular and fluorescent…
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Saturday, 29 July 2017 10:09

TERMINOLOGIES USED IN FLOWCYTOMETRY

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Principle of working of a flow cytometer
Fluorescence   A fluorochrome absorbs light energy and emits excess energy in the form of…
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Friday, 28 July 2017 12:59

COMMON APPLICATIONS OF FLOW CYTOMETRY IN HEMATOLOGY

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Principle of working of a flow cytometer
Leukemias and lympomas: Immunophenotyping (evaluation of cell surface markers), diagnosis, detection of minimal residual disease,…
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Friday, 28 July 2017 05:05

PLATELET AGGREGATION STUDIES

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Table 804.1 Laboratory features of platelet function disorders
Platelet aggregation tests are carried out in specialized hematology laboratories if platelet dysfunction is suspected.…
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Thursday, 27 July 2017 06:22

EXAMINATION OF BLOOD SMEAR

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Area for examination of blood cells and for differential cell count in blood smear
A blood smear is examined for:   Red cells: Morphology, immature forms, inclusion bodies, arrangement…
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Wednesday, 26 July 2017 12:45

MORPHOLOGY OF PLATELETS

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Figure 802.1 Causes of false thrombocytopenia on automated hematology analyzer: (A) Clumps of platelets; (B) Platelet satellitism
Platelets are small, 1-3 μm in diameter, purple structures with tiny irregular projections on surface.…
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