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Bite cells

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Term Definition
Bite cells

Abnormally-shaped red blood cells with one or more semicircular portions removed from the cell margin, appearing as though the cells have had "bite" or "bites." The "bites" result from the removal of hemoglobin with an altered structure (denatured) by special cells (macrophages) in the spleen. G6PD deficiency is a common disorder that leads to the formation of bite cells, which can be seen in a stained blood smear.