In long-standing Diabetes Mellitus (DM) of both types, a wide variety of lesions develop in many organs, which are important causes of morbidity and mortality.

Diabetes mellitus (DM) is a metabolic group of disorders characterized by persistent hyperglycemia due to deficiency and/or diminished effectiveness of insulin. There are derangements of carbohydrate, protein, and fat metabolism due to failure of insulin action on target cells.