Prediabetes is a state in which plasma glucose level is higher than normal but not high enough for the diagnosis of Diabetes Mellitus (DM).
In long-standing Diabetes Mellitus (DM) of both types, a wide variety of lesions develop in many organs, which are important causes of morbidity and mortality.

Metabolic Effects of Insulin

Insulin is the major hormone regulating blood glucose level. Insulin is synthesized by β cells of pancreas as preproinsulin, which is rapidly converted to proinsulin. Proinsulin is a single chain polypeptide. In the Golgi apparatus, proinsulin is broken down into 2 units- insulin (51 amino acids) and C (connecting)-polypeptide (31 amino acids) (Figure 1192.1).
Diabetes mellitus (DM) is a metabolic group of disorders characterized by persistent hyperglycemia due to deficiency and/or diminished effectiveness of insulin. There are derangements of carbohydrate, protein, and fat metabolism due to failure of insulin action on target cells.
Diabetes is epidemic; there is barely any family left that does not have a member diagnosed with diabetes. In urban areas, almost one-tenth of people have diabetes, and at least one-third are at risk of developing it soon if they do not do something about it. That means if not diabetic, every family surely has someone with prediabetes.

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