Displaying items by tag: Books

Description: p53 has emerged as a key tumor suppressor and important target for novel cancer therapy. This book, written by world-leading p53 researchers including many of those who have shaped the field over the past 25 years, provides unique insights into the progress of the field and the prospects for better cancer diagnosis and therapy in the future.

Description: Black's Medical Dictionary first appeared in 1906. That new century was to see health care in the United Kingdom evolve from a largely personal, paternalistic consultation between doctor and patient, based more on medical tradition than medical science, to a complex, science-based, team-oriented and managed service. The emergence of the informed patient was largely responsible for this change, and publications like this dictionary, the contents of which have during its forty-one editions reflected these changes in medicine, have served as a catalyst. The forty-first edition of Black's Medical Dictionary provides over 5,000 definitions and descriptions of medical terms and concepts, along with over 100 diagrams and drawings including several pages of color illustrations, and is accompanied by appendixes on important subjects such as the National Health Service (including selected statistics), Health Economics, Complementary and Alternative Medicine, Common Medical Tests, and an address list of support and professional organizations. Where relevant, entries contain appropriate cross-references to further information. All material has been checked and updated with new or substantially revised entries. This home compendium is invaluable for all who need an authoritative one-volume medical reference book.

Description: Diagnostic Pediatric Hematopathology is unique in providing an accurate and up-to-date guide to the diagnosis of benign and malignant hematologic disorders of childhood. The text discusses the development of the hematopoietic and lymphoid systems - and how this affects normal and abnormal findings in children at various ages. Also examined are the morphologic, immunophenotypic, cytogenetic, and molecular genetic characteristics of most pediatric-specific hematologic diseases. This is an excellent reference that ensures accurate diagnoses when evaluating peripheral blood, bone marrow, and lymph nodes of children. The text is written by a team of experienced pediatric hematopathologists and clinical scientists drawn from major academic children's hospitals in the United States, United Kingdom, and Canada. It will be a valuable tool in the every day practice of pathologists, pediatric pathologists, and hematopathologists, and a ready educational resource for fellows, pathology residents, medical students, clinical scientists in the field, and pediatric hematologists/oncologists.

Description: Determining and understanding the molecular mechanisms of disease is one of the key goals of modern medical research. The studies of medical genetics, microbiology, immunology, structural biology, molecular cell biology, neuroscience and developmental biology have been brought to bear on the full range of human diseases. This comprehensive Encyclopedia supplies the reader with concise information on molecular pathophysiology of human disease. Entries include both defined diseases (such as Parkinson's disease) and pathophysiological entities (such as tremor). The more than 1,200 entries are structured to allow rapid retrieval of information. For more detailed reading, each entry is followed by up to 5 references. The individual entries are written by leading experts in the respective area of research to ensure state-of-the-art descriptions of the mechanisms involved.

Description: The first part of the book focuses on indications and results of transplantation for acute leukemias, chronic myelogenous leukemia, lymphoma, multiple myeloma, and breast cancer, providing insight into the relative merits of transplant and nontransplant approaches to these disorders. Part II examines transplant-related complications including the pathophysiology and clinical consequences of acute and chronic GVHD, delayed immune reconstitution leading to infectious complications, and organ damage to the lung and liver.

Description: Based on Lever's Histopathology of the Skin, Second Edition, this full-color atlas presents an algorithmic pattern recognition approach to differential diagnosis of skin diseases. Whereas Lever's classifies diseases by pathogenesis, this atlas aids in differential diagnosis of unknown cases by classifying diseases morphologically, based on their location in the skin and the patterns and cell types seen through the microscope. Within each morphologic category, prototypic disorders are described and illustrated with full-color photomicrographs, and a list of differential diagnostic possibilities is presented. The atlas contains over 1,300 full-color illustrations.

Cytopreparation: Principles and Practice by Gary W. Gill fills a long-standing need for an easy-to-use and authoritative manual on the fundamentals of cytopreparation up-to-and- including microscopy, screening, and data analysis. The text describes in phenomenological terms the most common materials and methods of specimen collection through mounting for gyn, non-gyn, and FNA specimens, as well as the underlying mechanistic bases. The author provides his expertise and information that will empower and enable readers to review and improve their laboratories’ cytopreparatory techniques as they apply to the vast majority of specimens. This unique volume provides facts that are not readily available anywhere. Cytopreparation: Principles & Practice is intended for everyone associated with, and involved in, making cytologic preparations that are useful for their intended purpose. It will serve as a valuable reference tool for educators in cytology and histology, cytotechnology and histotechnology students, cytotechnologists, cytopreparatory technicians, cytopathologists, anatomical/clinical pathologists, pathology residents and cytopathology fellows.

Description: This companion monograph to West's Respiratory Physiology covers normal respiratory function and focuses on the function of the diseased lung. Pulmonary Pathophysiology: The Essentials offers a concise overview of the diseased states of the lung, emphasizing structure and function. The Eighth Edition is updated to include new information on asthma therapies, new radiographs and micrographs, extended sections on infections and cancer, more thorough explanations for review questions, and a new summary appendix of equations with sample calculations.

Description: One of the best-selling medical textbooks of all time, Robbins and Cotran Pathologic Basis of Disease is the one book that nearly all medical students purchase, and is also widely used by physicians worldwide. A "who's who" of pathology experts delivers the most dependable, current, and complete coverage of today's essential pathology knowledge. At the same time, masterful editing and a practical organization make mastering every concept remarkably easy. Online access via Student Consult includes self-assessment and review questions, interactive case studies, downloadable images, videos, and a virtual microscope that lets you view slides at different magnifications. The result remains the ideal source for an optimal understanding of pathology. Offers the most authoritative and comprehensive, yet readable coverage available in any pathology textbook, making it ideal for USMLE or specialty board preparation as well as for course work. Includes access to the complete contents online via Student Consult, along with self-assessment and review questions, over 100 interactive clinical case studies, downloadable images, videos, and a virtual microscope that lets users view slides at different magnifications. Delivers a state-of-the-art understanding of the pathologic basis of disease through completely updated coverage, including the latest cellular and molecular biology. Demonstrates every concept visually with over 1,600 full-color photomicrographs and conceptual diagrams - many revised for even better quality. Facilitates learning with an outstanding full-color, highly user-friendly design.

Description: This book provides a comprehensive overview in our understanding of the biology and therapeutic potential of hematopoietic stem cells, and is aimed at those engaged in stem cell research: undergraduate and postgraduate science students, investigators and clinicians. Starting from fundamental principles in hematopoiesis, Advances in Hematopoietic Stem Cell Research assemble a wealth of information relevant to central mechanisms that may regulate differentiation, and expansion of hematopoietic stem cells in normal conditions and during disease. Starting from fundamental principles in hematopoiesis, Advances in Hematopoietic Stem Cell Research assemble a wealth of information relevant to central mechanisms that may regulate differentiation, and expansion of hematopoietic stem cells in normal conditions and during disease.

Description: Multiple Myeloma (MM), the second most common blood cancer in adults, is a clonal plasma cell malignancy within the bone marrow characterized by osteolytic bone lesions, renal disease, and immunodeficiency. It is now well established that MM cell- induced disruption of the bone marrow homeostasis between the highly organized cellular and extracellular compartments supports MM cell proliferation, survival, migration, and drug resistance via activation of various signaling pathways. Based on this knowledge, the prototypic drugs thalidomide, bortezomib, and lenalidomide, which target both MM cells and the bone marrow microenvironment, have already fundamentally changed treatment options of this disease. Indeed, their benefit is now not only shown in relapsed and refractory disease but they also improve overall response, duration of response, and progression-free and overall survival when used as part of first-line regimens. However, despite new insights into MM pathogenesis and exciting derived therapeutic advances, MM still remains incurable. Ongoing studies are therefore aiming to further delineate mechanisms of MM pathogenesis within the bone marrow to identify novel agents with enhanced cytotoxicity and decreased drug resistance to improve patient outcome. Multiple Myeloma - A New Era of Treatment Strategies is devoted to contributions from eminent scientists providing readers with comprehensive accounts of the most recent developments in the field of MM research. It addresses the interests of scientists and clinical investigators in MM research as well as other fields of oncology, in which the microenvironment is believed to play an important role.

Description: The book Radioisotopes-Applications in Bio-Medical Science contains two sections: Radioisotopes and Radiations in Bioscience and Radioisotopes and Radiology in Medical Science. Section I includes chapters on radioisotope production, radio-labeled nano-particles, radioisotopes and nano-medicine, use of radiations in insects, drug research, medical radioisotopes and use of radioisotopes in interdisciplinary fields etc. In Section II, chapters related to production of metal PET (positron emission tomography) radioisotopes, 3-dimensional and CT (computed tomography) scan, SS nuclear medicine in imaging, cancer diagnose and treatments have been included. The subject matter will by highly useful to the medical and paramedical staff in hospitals, as well as researchers and scholars in the field of nuclear medicine medical physics and nuclear bio-chemistry etc.

Description: With cancer-related deaths projected to rise to 10.3 million people by 2020, the need to prevent, diagnose, and cure cancer is greater than ever. This book presents readers with the most up-to-date imaging instrumentation, general and diagnostic applications for various cancers, with an emphasis on lung and breast carcinomas--the two major worldwide malignancy types. This book discusses the various imaging techniques used to locate and diagnose tumors, including ultrasound, X-ray, color Doppler sonography, PET, CT, PET/CT, MRI, SPECT, diffusion tensor imaging, dynamic infrared imaging, and magnetic resonance spectroscopy. It also details strategies for imaging cancer, emphasizing the importance of the use of this technology for clinical diagnosis. Imaging techniques that predict the malignant potential of cancers, response to chemotherapy and other treatments, recurrence, and prognosis are also detailed. Concentrates on the application of imaging technology to the diagnosis and prognosis of lung and breast carcinomas, the two major worldwide malignancies Addresses the relationship between radiation dose and image quality Discusses the role of molecular imaging in identifying changes for the emergence and progression of cancer at the cellular and/or molecular levels

Description: This book Edited by Larry C. James, Wright State University, Dayton, OH, USA John Linton, West Virginia University School of Medicine, Charleston Environmental, genetic, psychological, and societal factors interact to produce obesity, a chronic condition of epidemic proportions. The Handbook of Obesity Intervention for the Lifespan guides professionals in meeting this complex challenge with a multidisciplinary palette of evidence-based interventions that can be tailored to men and women across the lifespan, regardless of background. This unique reference combines salient research data and hands-on clinical applications for use with overweight patients, from the very young to the very old, and includes a “treatment resources” section with extra materials to bolster therapy-all geared toward respectful, encouraging treatment and lasting weight-loss results. Key features of the Handbook: Review of the obesity literature, both pediatric and adult. Exercise interventions for children and adults. Lifestyle interventions for adolescents, adults, and seniors. Weight-related cultural issues throughout the lifespan. Bariatric surgery: when is it indicated? How successful is it? The ten critical steps to healthy weight loss. Clinical resources, patient self-help materials, and useful websites. With excess weight contributing to some 300,000 deaths in the U.S. each year, the Handbook of Obesity Intervention for the Lifespan will be welcomed-and consulted frequently-by clinical and health psychologists, psychiatrists, primary care providers, and nutritionists.

Description: Neuroimaging in Addiction presents an up-to-date, comprehensive review of the functional and structural imaging human studies that have greatly advanced our understanding of this complex disorder. Approaching addiction from a conceptual rather than a substance-specific perspective, this book integrates broad neuropsychological constructs that consider addiction as a neuroplastic process with genetic, developmental, and substance-induced contributions. The internationally recognized contributors to this volume are leaders in clinical imaging with expertise that spans the addiction spectrum. Following a general introduction, an overview of neural circuitry and modern non-invasive imaging techniques provides the framework for subsequent chapters on reward salience, craving, stress, impulsivity and cognition. Additional topics include the use of neuroimaging for the assessment of acute drug effects, drug-induced neurotoxicity, non-substance addictive behaviors, and the application of imaging genetics to identify unique intermediate phenotypes. The book concludes with an exploration of the future promise for functional imaging as guide to the diagnosis and treatment of addictive disorders. Scientists and clinicians will find the material in this volume invaluable in their work towards understanding the addicted brain, with the overall goal of improved prevention and treatment outcomes for patients. Features a Foreword by Edythe London, Director of the Center for Addictive Behaviors, University of California at Los Angeles.

Description: Modern neuroimaging offers tremendous opportunities for gaining insights into normative development and a wide array of developmental neuropsychiatric disorders. Focusing on ontogeny, this text covers basic processes involved in both healthy and atypical maturation, and also addresses the range of neuroimaging techniques most widely used for studying children. This book will enable you to understand normative structural and functional brain maturation and the mechanisms underlying basic developmental processes; become familiar with current knowledge and hypotheses concerning the neural bases of developmental neuropsychiatric disorders; and learn about neuroimaging techniques, including their unique strengths and limitations. Coverage includes normal developmental processes, atypical processing in developmental neuropsychiatric disorders, ethical issues, neuroimaging techniques and their integration with psychopharmacologic and molecular genetic research approaches, and future directions. This comprehensive volume is an essential resource for neurologists, neuropsychologists, psychiatrists, pediatricians, and radiologists concerned with normal development and developmental neuropsychiatric disorders.